Article
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
Science (New York, N.Y.) - 1 Jun 2007
Zeggini Eleftheria, Weedon Michael N, Lindgren Cecilia M, Frayling Timothy M, Elliott Katherine S, Lango Hana, Timpson Nicholas J, Perry John R B, Rayner Nigel W, Freathy Rachel M, Barrett Jeffrey C, Shields Beverley, Morris Andrew P, Ellard Sian, Groves Christopher J, Harries Lorna W, Marchini Jonathan L, Owen Katharine R, Knight Beatrice, Cardon Lon R, Walker Mark, Hitman Graham A, Morris Andrew D, Doney Alex S F, McCarthy Mark I, Hattersley Andrew T
Abstract excerpt
The molecular mechanisms involved in the development of type 2 diabetes are poorly understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 population controls generated by the Wellcome Trust Case Control Consortium, we set out to detect replicated diabetes association signals through analysis of 3757 additional cases and 5346 controls and by integration of our findings with equivalent...
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