Article
A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q.
American journal of human genetics - 1 Sept 2001
Wiltshire S, Hattersley A T, Hitman G A, Walker M, Levy J C, Sampson M, O'Rahilly S, Frayling T M, Bell J I, Lathrop G M, Bennett A, Dhillon R, Fletcher C, Groves C J, Jones E, Prestwich P, Simecek N, Rao P V, Wishart M, Bottazzo G F, Foxon R, Howell S, Smedley D, Cardon L R, Menzel S, McCarthy M I
Abstract excerpt
Improved molecular understanding of the pathogenesis of type 2 diabetes is essential if current therapeutic and preventative options are to be extended. To identify diabetes-susceptibility genes, we have completed a primary (418-marker, 9-cM) autosomal-genome scan of 743 sib pairs (573 pedigrees) with type 2 diabetes who are from the Diabetes UK Warren 2 repository. Nonparametric linkage analysis of the entire...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.