Article

Enhanced genetic analysis of type 1 diabetes by selecting variants on both effect size and significance, and by integration with autoimmune thyroid disease

2021-02-06

Abstract excerpt

For polygenic traits, associations with genetic variants can be detected over many chromosome regions, owing to the availability oflarge sample sizes. Most variants, however, have small effects on disease risk and, therefore, unravelling the causal variants, target genes, and biology of these variants is challenging. Here, we define the Bigger or False Discovery Rate (BFDR) as the probability that either a variant...

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Literature Corpus work: 3b71c41c-5e5b-5e7e-99e1-1245127a59aa
DOI: 10.1101/2021.02.05.429962

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