Article
The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports.
BMC medical genetics - 1 Jan 2007
Cupples L Adrienne, Arruda Heather T, Benjamin Emelia J, D'Agostino Ralph B, Demissie Serkalem, DeStefano Anita L, Dupuis Josée, Falls Kathleen M, Fox Caroline S, Gottlieb Daniel J, Govindaraju Diddahally R, Guo Chao-Yu, Heard-Costa Nancy L, Hwang Shih-Jen, Kathiresan Sekar, Kiel Douglas P, Laramie Jason M, Larson Martin G, Levy Daniel, Liu Chun-Yu, Lunetta Kathryn L, Mailman Matthew D, Manning Alisa K, Meigs James B, Murabito Joanne M, Newton-Cheh Christopher, O'Connor George T, O'Donnell Christopher J, Pandey Mona, Seshadri Sudha, Vasan Ramachandran S, Wang Zhen Y, Wilk Jemma B, Wolf Philip A, Yang Qiong, Atwood Larry D
Abstract excerpt
BACKGROUND: The Framingham Heart Study (FHS), founded in 1948 to examine the epidemiology of cardiovascular disease, is among the most comprehensively characterized multi-generational studies in the world. Many collected phenotypes have substantial genetic contributors; yet most genetic determinants remain to be identified. Using single nucleotide polymorphisms (SNPs) from a 100K genome-wide scan, we examine the...
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