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Article

Identification of a region in the TASK3 two pore domain potassium channel that is critical for its blockade by methanandamide.

British journal of pharmacology - 1 Nov 2007

Veale E L, Buswell R, Clarke C E, Mathie A

Abstract excerpt

BACKGROUND AND PURPOSE: The TASK subfamily of two pore domain potassium channels (K2P) encodes for leak K currents, contributing to the resting membrane potential of many neurons and regulating their excitability. TASK1 and TASK3 channels are regulated by a number of pharmacological and physiolog...

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Source

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Identifiers

PMID: 17828294
DOI: 10.1038/sj.bjp.0707436
PMCID: PMC2190017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17828294-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

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Identification of a region in the TASK3 two pore domain potassium channel that is critical for its blockade by methanandamide.PMID 17828294Read ↗

A unique lower X-gate in TASK channels traps inhibitors within the vestibuleSemantic proximity Read ↗

A lower X-gate in TASK channels traps inhibitors within the vestibule.Semantic proximity Read ↗

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TASK-1 (KCNK3) channels in the lung: from cell biology to clinical implications.Semantic proximity Read ↗

Recovery of current through mutated TASK3 potassium channels underlying Birk Barel syndrome.Semantic proximity Read ↗

Inhibitory effect of 17β-estradiol on the THIK-1 channel.Semantic proximity Read ↗

Cannabinoid inhibition of mechanosensitive K+ channelsSemantic proximity Read ↗

The M1P1 loop of TASK3 K2P channels apposes the selectivity filter and influences channel function.Semantic proximity Read ↗

TASK1 (K(2P)3.1) K(+) channel inhibition by endothelin-1 is mediated through Rho kinase-dependent phosphorylation.Semantic proximity Read ↗

State-dependent blocking mechanism of Kv 1.3 channels by the antimycobacterial drug clofazimine.Semantic proximity Read ↗

Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function.Semantic proximity Read ↗

Aristolochic acid, a plant extract used in the treatment of pain and linked to Balkan endemic nephropathy, is a regulator of K2P channelsSemantic proximity Read ↗

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