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Article

Inhibitory effect of 17β-estradiol on the THIK-1 channel.

PloS one - 1 Jan 2026

Tateyama Michihiro, Kubo Yoshihiro

Abstract excerpt

A two-pore domain K+ (K2P) channel, THIK-1, plays important roles in microglia and macrophage. THIK-1 is known to be activated by arachidonic acid and G protein-coupled receptors and inhibited by anesthetics. Steroids, such as cholesterol, estradiol and progesterone, are known to modulate several K+ channels and they might be potential modulators of THIK-1. We examined the effects of steroids on THIK-1 and found...

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Estradiol
Mice
Molecular Docking Simulation
Mutation
Potassium Channels, Tandem Pore Domain
Progesterone

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Identifiers

PMID: 42467728
DOI: 10.1371/journal.pone.0353757
PMCID: PMC13379078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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