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Article

Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function.

Proceedings of the National Academy of Sciences of the United States of America - 24 Jun 2003

Pei Lin, Wiser Ofer, Slavin Anthony, Mu David, Powers Scott, Jan Lily Yeh, Hoey Timothy

Abstract excerpt

TASK3 gene (Kcnk9) is amplified and overexpressed in several types of human carcinomas. In this report, we demonstrate that a point mutation (G95E) within the consensus K+ filter of TASK3 not only abolished TASK3 potassium channel activity but also abrogated its oncogenic functions, including proliferation in low serum, resistance to apoptosis, and promotion of tumor growth. Furthermore, we provide evidence that...

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Identifiers

PMID: 12782791
DOI: 10.1073/pnas.1232448100
PMCID: PMC164668

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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