Article
Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells.
PloS one - 21 Apr 2011
Alagramam Kumar N, Goodyear Richard J, Geng Ruishuang, Furness David N, van Aken Alexander F J, Marcotti Walter, Kros Corné J, Richardson Guy P
Abstract excerpt
Immunocytochemical studies have shown that protocadherin-15 (PCDH15) and cadherin-23 (CDH23) are associated with tip links, structures thought to gate the mechanotransducer channels of hair cells in the sensory epithelia of the inner ear. The present report describes functional and structural analyses of hair cells from Pcdh15(av3J) (av3J), Pcdh15(av6J) (av6J) and Cdh23(v2J) (v2J) mice. The av3J and v2J mice...
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