Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction.

Nature - 6 Dec 2012

Sotomayor Marcos, Weihofen Wilhelm A, Gaudet Rachelle, Corey David P

Abstract excerpt

Hearing and balance use hair cells in the inner ear to transform mechanical stimuli into electrical signals. Mechanical force from sound waves or head movements is conveyed to hair-cell transduction channels by tip links, fine filaments formed by two atypical cadherins known as protocadherin 15 and cadherin 23 (refs 4, 5). These two proteins are involved in inherited deafness and feature long extracellular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cadherin Related Proteins
Share to Cadherins
Share to Chromatography, Gel

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Deafness

Share to Ear, Inner

Share to Mechanotransduction, Cellular

Share to Protein Precursors

Share to Repetitive Sequences, Amino Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 23135401
DOI: 10.1038/nature11590
PMCID: PMC3518760

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction.PMID 23135401Read ↗

Nanomechanics of wild-type and mutant dimers of the inner-ear tip-link protein protocadherin 15.Semantic proximity Read ↗

Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells.Semantic proximity Read ↗

Tip links in hair cells: molecular composition and role in hearing lossSemantic proximity Read ↗

A Partial Calcium-Free Linker Confers Flexibility to Inner-Ear Protocadherin-15.Semantic proximity Read ↗

Cadherins and mechanotransduction by hair cells.Semantic proximity Read ↗

The Dynamic Strength of the Hair-Cell Tip Link Reveals Mechanisms of Hearing and DeafnessSemantic proximity Read ↗

Structure of the N terminus of cadherin 23 reveals a new adhesion mechanism for a subset of cadherin superfamily members.Semantic proximity Read ↗

Noddy, a mouse harboring a missense mutation in protocadherin-15, reveals the impact of disrupting a critical interaction site between tip-link cadherins in inner ear hair cells.Semantic proximity Read ↗

Cryo-EM reveals a right-handed double-helix dimer architecture of PCDH15.Semantic proximity Read ↗

Elasticity and Thermal Stability are Key Determinants of Hearing Rescue by Mini-Protocadherin-15 ProteinsSemantic proximity Read ↗

Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells.Semantic proximity Read ↗

Single-molecule force spectroscopy reveals the dynamic strength of the hair-cell tip-link connection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.