Article
Noddy, a mouse harboring a missense mutation in protocadherin-15, reveals the impact of disrupting a critical interaction site between tip-link cadherins in inner ear hair cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 6 Mar 2013
Geng Ruishuang, Sotomayor Marcos, Kinder Kimberly J, Gopal Suhasini R, Gerka-Stuyt John, Chen Daniel H-C, Hardisty-Hughes Rachel E, Ball Greg, Parker Andy, Gaudet Rachelle, Furness David, Brown Steve D, Corey David P, Alagramam Kumar N
Abstract excerpt
In hair cells of the inner ear, sound or head movement increases tension in fine filaments termed tip links, which in turn convey force to mechanosensitive ion channels to open them. Tip links are formed by a tetramer of two cadherin proteins: protocadherin 15 (PCDH15) and cadherin 23 (CDH23), which have 11 and 27 extracellular cadherin (EC) repeats, respectively. Mutations in either protein cause inner ear...
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