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Article

Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells.

Nature - 29 Apr 2004

Söllner Christian, Rauch Gerd-Jörg, Siemens Jan, Geisler Robert, Schuster Stephan C, Müller Ulrich, Nicolson Teresa

Abstract excerpt

Hair cells have highly organized bundles of apical projections, or stereocilia, that are deflected by sound and movement. Displacement of stereocilia stretches linkages at the tips of stereocilia that are thought to gate mechanosensory channels. To identify the molecular machinery that mediates mechanotransduction in hair cells, zebrafish mutants were identified with defects in balance and hearing. In sputnik...

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Identifiers

PMID: 15057246
DOI: 10.1038/nature02484

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells.PMID 15057246Read ↗

Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells.Semantic proximity Read ↗

Harmonin mutations cause mechanotransduction defects in cochlear hair cells.Semantic proximity Read ↗

Compound heterozygosity of the functionally null Cdh23(v-ngt) and hypomorphic Cdh23(ahl) alleles leads to early-onset progressive hearing loss in mice.Semantic proximity Read ↗

Cadherins and mechanotransduction by hair cells.Semantic proximity Read ↗

Tip links in hair cells: molecular composition and role in hearing lossSemantic proximity Read ↗

Spatiotemporal pattern and isoforms of cadherin 23 in wild type and waltzer mice during inner ear hair cell development.Semantic proximity Read ↗

Presence of interstereocilial links in waltzer mutants suggests Cdh23 is not essential for tip link formation.Semantic proximity Read ↗

Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells.Semantic proximity Read ↗

Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction.Semantic proximity Read ↗

MAGI-1, A Candidate Stereociliary Scaffolding Protein, Associates with the Tip-Link Component Cadherin 23Semantic proximity Read ↗

Progressive hearing loss and increased susceptibility to noise-induced hearing loss in mice carrying a Cdh23 but not a Myo7a mutation.Semantic proximity Read ↗

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