Article
Structure of the N terminus of cadherin 23 reveals a new adhesion mechanism for a subset of cadherin superfamily members.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jun 2010
Elledge Heather M, Kazmierczak Piotr, Clark Peter, Joseph Jeremiah S, Kolatkar Anand, Kuhn Peter, Müller Ulrich
Abstract excerpt
The cadherin superfamily encodes more than 100 receptors with diverse functions in tissue development and homeostasis. Classical cadherins mediate adhesion by binding interactions that depend on their N-terminal extracellular cadherin (EC) domains, which swap N-terminal beta-strands. Sequence alignments suggest that the strand-swap binding mode is not commonly used by functionally divergent cadherins. Here, we...
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