Article
Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity.
Molecular and cellular neurosciences - 1 Dec 2008
Walters B J, Campbell S L, Chen P C, Taylor A P, Schroeder D G, Dobrunz L E, Artavanis-Tsakonas K, Ploegh H L, Wilson J A, Cox G A, Wilson S M
Abstract excerpt
The ubiquitin proteasome pathway has been implicated in the pathogenesis of many neurodegenerative diseases, and alterations in two different deubiquitinating enzymes, Uch-L1 and Usp14, result in neurological phenotypes in mice. We identified a new mutation in Uch-L1 and compared the roles of Uch-L1 and Usp14 in the ubiquitin proteasome system. Deficiencies in either Uch-L1 or Usp14 result in decreased levels of...
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