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Article

Control of rapsyn stability by the CUL-3-containing E3 ligase complex.

The Journal of biological chemistry - 20 Mar 2009

Nam Seunghee, Min Kyoengwoo, Hwang Hyejin, Lee Hae-Ock, Lee Jung Hwa, Yoon Jongbok, Lee Hyunsook, Park Sungsu, Lee Junho

Abstract excerpt

Rapsyn is a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. Here we report the mechanism for posttranslational control of rapsyn protein stability. We confirmed that C18H9.7-encoded RPY-1 is a rapsyn homolog in Caenorhabditis elegans by showing that human rapsyn rescued rpy-1 mutant phenotypes in nematodes, as determined by levamisole...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Myasthenic Syndromes, Congenital

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Source

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Identifiers

PMID: 19158078
DOI: 10.1074/jbc.M808230200
PMCID: PMC3282941

Genes

KEL
UBC
CUL3
KLHL8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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