Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The effects of NOS2 gene deletion on mice expressing mutated human AbetaPP.

Journal of Alzheimer's disease : JAD - 1 Dec 2008

Colton Carol A, Wilcock Donna M, Wink David A, Davis Judianne, Van Nostrand William E, Vitek Michael P

Abstract excerpt

Nitric oxide synthase 2 (NOS2) and its gene product, inducible NOS (iNOS) play an important role in neuroinflammation by generating nitric oxide (NO), a critical signaling and redox factor in the brain. Although NO is associated with tissue damage, it can also promote cell survival. We hypothesize that during long-term exposure to amyloid-beta (Abeta) in Alzheimer's disease (AD), NO levels fall in the brain to a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Amyloid beta-Protein Precursor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chronic Disease

Share to Gene Deletion

Share to Inflammation

Share to Mice, Transgenic

Share to Nitric Oxide Synthase Type II

Source

Open in PubMed Open full text

Identifiers

PMID: 19096157
DOI: 10.3233/jad-2008-15405
PMCID: PMC2667339

Genes

NOS2
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The effects of NOS2 gene deletion on mice expressing mutated human AbetaPP.PMID 19096157Read ↗

mNos2 deletion and human NOS2 replacement in Alzheimer disease models.Semantic proximity Read ↗

Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formation.Semantic proximity Read ↗

Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease.Semantic proximity Read ↗

Genetic deletion of nitric oxide synthase 2 ameliorates Parkinson’s disease pathology and neuroinflammation in a transgenic mouse model of synucleinopathySemantic proximity Read ↗

Enhanced astrocytic nitric oxide production and neuronal modifications in the neocortex of a NOS2 mutant mouse.Semantic proximity Read ↗

Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthaseSemantic proximity Read ↗

Reversing increased neuronal nitric oxide synthase in Alzheimer’s disease prevents aberrant glutamatergic calcium responsesSemantic proximity Read ↗

Degeneration of NO-synthesizing cerebrocortical neurons in transgenic mice expressing mutated superoxide dismutase is not due to elevated nitric oxide levels.Semantic proximity Read ↗

Endothelial nitric oxide deficiency promotes Alzheimer's disease pathology.Semantic proximity Read ↗

Early Induction of Oxidative Stress in Mouse Model of Alzheimer Disease with Reduced Mitochondrial Superoxide Dismutase ActivitySemantic proximity Read ↗

Aging-related increase in oxidative stress correlates with developmental pattern of beta-secretase activity and beta-amyloid plaque formation in transgenic Tg2576 mice with Alzheimer-like pathology.Semantic proximity Read ↗

Altered neuronal nitric oxide synthase expression contributes to disease progression in Huntington’s disease transgenic miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.