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Article

mNos2 deletion and human NOS2 replacement in Alzheimer disease models.

Journal of neuropathology and experimental neurology - 1 Aug 2014

Colton Carol A, Wilson Joan G, Everhart Angela, Wilcock Donna M, Puoliväli Jukka, Heikkinen Taneli, Oksman Juho, Jääskeläinen Olli, Lehtimäki Kimmo, Laitinen Teemu, Vartiainen Nina, Vitek Michael P

Abstract excerpt

Understanding the pathophysiologic mechanisms underlying Alzheimer disease relies on knowledge of disease onset and the sequence of development of brain pathologies. We present a comprehensive analysis of early and progressive changes in a mouse model that demonstrates a full spectrum of characteristic Alzheimer disease-like pathologies. This model demonstrates an altered immune redox state reminiscent of the...

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Identifiers

PMID: 25003233
DOI: 10.1097/NEN.0000000000000094
PMCID: PMC4131941

Genes

NOS2

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