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Article

Regulation of brain glutamate metabolism by nitric oxide and S-nitrosylation.

Science signaling - 7 Jul 2015

Raju Karthik, Doulias Paschalis-Thomas, Evans Perry, Krizman Elizabeth N, Jackson Joshua G, Horyn Oksana, Daikhin Yevgeny, Nissim Ilana, Yudkoff Marc, Nissim Itzhak, Sharp Kim A, Robinson Michael B, Ischiropoulos Harry

Abstract excerpt

Nitric oxide (NO) is a signaling intermediate during glutamatergic neurotransmission in the central nervous system (CNS). NO signaling is in part accomplished through cysteine S-nitrosylation, a posttranslational modification by which NO regulates protein function and signaling. In our investigation of the protein targets and functional impact of S-nitrosylation in the CNS under physiological conditions, we...

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Identifiers

PMID: 26152695
DOI: 10.1126/scisignal.aaa4312
PMCID: PMC4746709

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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