Article
High-throughput methylation profiling by MCA coupled to CpG island microarray.
Genome research - 1 Oct 2007
Estécio Marcos R H, Yan Pearlly S, Ibrahim Ashraf E K, Tellez Carmen S, Shen Lanlan, Huang Tim H-M, Issa Jean-Pierre J
Abstract excerpt
An abnormal pattern of DNA methylation occurs at specific genes in almost all neoplasms. The lack of high-throughput methods with high specificity and sensitivity to detect changes in DNA methylation has limited its application for clinical profiling. Here we overcome this limitation and present an improved method to identify methylated genes genome-wide by hybridizing a CpG island microarray with amplicons...
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