DNA methylation markers for diagnosis and prognosis of common cancers.

doi:10.1073/pnas.1703577114

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Article

DNA methylation markers for diagnosis and prognosis of common cancers.

Proceedings of the National Academy of Sciences of the United States of America - 11 Jul 2017

Hao Xiaoke, Luo Huiyan, Krawczyk Michal, Wei Wei, Wang Wenqiu, Wang Juan, Flagg Ken, Hou Jiayi, Zhang Heng, Yi Shaohua, Jafari Maryam, Lin Danni, Chung Christopher, Caughey Bennett A, Li Gen, Dhar Debanjan, Shi William, Zheng Lianghong, Hou Rui, Zhu Jie, Zhao Liang, Fu Xin, Zhang Edward, Zhang Charlotte, Zhu Jian-Kang, Karin Michael, Xu Rui-Hua, Zhang Kang

Abstract excerpt

The ability to identify a specific cancer using minimally invasive biopsy holds great promise for improving the diagnosis, treatment selection, and prediction of prognosis in cancer. Using whole-genome methylation data from The Cancer Genome Atlas (TCGA) and machine learning methods, we evaluated the utility of DNA methylation for differentiating tumor tissue and normal tissue for four common cancers (breast,...

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Identifiers

PMID: 28652331
DOI: 10.1073/pnas.1703577114
PMCID: PMC5514741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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