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Genome-Scale Methylation Analysis of Circulating Cell-Free DNA in Gastric Cancer Patients

23 Sept 2021

Abstract excerpt

BACKGROUND: Aberrant DNA hypermethylation of CpG islands (CGIs) occurs frequently and is genome-wide in human gastric cancer (GC). A DNA methylation approach in plasma cell-free DNA (cfDNA) is attractive for the noninvasive detection of GC. Here, we performed genome-scale cfDNA methylation analysis in patients with GC. METHODS: We used MCTA-Seq, a genome-scale DNA methylation analysis method, on the plasma...

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PMID: 34791072
DOI: 10.1093/clinchem/hvab204

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