Article
Evolution of neoplastic development in the liver of transgenic mice co-expressing c-myc and transforming growth factor-alpha.
The American journal of pathology - 1 Aug 1996
Santoni-Rugiu E, Nagy P, Jensen M R, Factor V M, Thorgeirsson S S
Abstract excerpt
We have previously shown that co-expression of c-myc and transforming growth factor (TGF)-alpha as transgenes in mouse liver results in major enhancement of neoplastic development in this organ as compared with expression of either of these transgenes alone. In this report we describe in detail the progression from liver cell dysplasia to hepatocellular carcinomas (HCCs) occurring in the liver of c-myc/TGF-alpha...
Topics
- Animals
- Apoptosis
- Blotting, Northern
- Disease Models, Animal
- Disease Progression
- Female
- Gene Expression Regulation, Neoplastic
- Immunohistochemistry
- Incidence
- Liver
- Liver Neoplasms
- Liver Transplantation
- Male
- Mice