Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mammalian E-type Cyclins Control Chromosome Pairing, Telomere Stability and CDK2 Localization in Male Meiosis

27 Feb 2014

Abstract excerpt

Loss of function of cyclin E1 or E2, important regulators of the mitotic cell cycle, yields viable mice, but E2-deficient males display reduced fertility. To elucidate the role of E-type cyclins during spermatogenesis, we characterized their expression patterns and produced additional deletions of Ccne1 and Ccne2 alleles in the germline, revealing unexpected meiotic functions. While Ccne2 mRNA and protein are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to Microtubule and mitosis dynamics
Share to Reproductive Biology and Fertility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24586195
DOI: 10.1371/journal.pgen.1004165

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mammalian E-type Cyclins Control Chromosome Pairing, Telomere Stability and CDK2 Localization in Male MeiosisPMID 24586195Read ↗

Role of cyclins in controlling progression of mammalian spermatogenesisSemantic proximity Read ↗

The A‐type cyclins and the meiotic cell cycle in mammalian male germ cellsSemantic proximity Read ↗

Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage ResponseSemantic proximity Read ↗

Genetic control of meiosis surveillance mechanisms in mammalsSemantic proximity Read ↗

Cyclin A1 is required for meiosis in the male mouse.Semantic proximity Read ↗

DMRT proteins and coordination of mammalian spermatogenesisSemantic proximity Read ↗

Poised chromatin and bivalent domains facilitate the mitosis-to-meiosis transition in the male germlineSemantic proximity Read ↗

Disruption of the ubiquitin ligase HERC4 causes defects in spermatozoon maturation and impaired fertilitySemantic proximity Read ↗

Cyclin A2 is essential for mouse gonocyte maturation.Semantic proximity Read ↗

The mammalian Doublesex homolog DMRT6 coordinates the transition between mitotic and meiotic developmental programs during spermatogenesis.Semantic proximity Read ↗

A mei-P26 is required for initiation of meiosis in the Drosophila male germline.Semantic proximity Read ↗

BRCA2 deficiency in mice leads to meiotic impairment and infertilitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.