Article

Bi-allelic missense variants in MEI4 cause preimplantation embryonic arrest and female infertility

2023-09-12

Abstract excerpt

Preimplantation embryonic arrest is an important pathogenesis of female infertility, but little is known about the genetic factors behind this phenotype. MEI4 is an essential protein for DNA double-strand break formation during meiosis, and Mei4 knock-out female mice are viable but sterile, indicating that MEI4 plays a crucial role in reproduction. To date, MEI4 has not been found to be associated with any human r...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8c543a58-8e53-502f-9946-bcde9ea56ea5
DOI: 10.21203/rs.3.rs-3330196/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Bi-allelic missense variants in MEI4 cause preimplantation embryonic arrest and female infertilityDOI 10.21203/rs.3.rs-3330196/v1Read

Bi-allelic missense variants in MEI4 cause preimplantation embryonic arrest and female infertility.Semantic proximity Read

Novel variants in MEI1 cause female infertility characterized by early embryonic arrest and implantation failure.Semantic proximity Read

MEI4 variations drive female reproductive disorders via impaired oocyte abundance and developmental potential.Semantic proximity Read

Novel biallelic mutations in MEI1: expanding the phenotypic spectrum to human embryonic arrest and recurrent implantation failure.Semantic proximity Read

Novel MEI1 mutations cause chromosomal and DNA methylation abnormalities leading to embryonic arrest and implantation failure.Semantic proximity Read

Polymorphic alleles of the human MEI1 gene are associated with human azoospermia by meiotic arrest.Semantic proximity Read

Biallelic mutations in <i>M1AP</i> are a frequent cause of meiotic arrest leading to male infertilitySemantic proximity Read

A new MEIOB mutation is a recurrent cause for azoospermia and testicular meiotic arrestSemantic proximity Read

Bi-allelic MEI1 variants cause meiosis arrest and non-obstructive azoospermiaSemantic proximity Read

A common cause of non-obstructive azoospermia: biallelic MEI1 variants and implications for infertility diagnostics.Semantic proximity Read

The genetics of human infertility by functional interrogation of SNPs in mice.Semantic proximity Read

Homozygous mutations in REC114 cause female infertility characterised by multiple pronuclei formation and early embryonic arrest.Semantic proximity Read