Article
A dominant, recombination-defective allele of Dmc1 causing male-specific sterility.
PLoS biology - 1 May 2007
Bannister Laura A, Pezza Roberto J, Donaldson Janet R, de Rooij Dirk G, Schimenti Kerry J, Camerini-Otero R Daniel, Schimenti John C
Abstract excerpt
DMC1 is a meiosis-specific homolog of bacterial RecA and eukaryotic RAD51 that can catalyze homologous DNA strand invasion and D-loop formation in vitro. DMC1-deficient mice and yeast are sterile due to defective meiotic recombination and chromosome synapsis. The authors identified a male dominant sterile allele of Dmc1, Dmc1(Mei11), encoding a missense mutation in the L2 DNA binding domain that abolishes strand...
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