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Article

Insertional versus targeted mutagenesis in mice.

The New biologist - 1 Nov 1991

Gridley T

Abstract excerpt

Recent innovations in mutagenesis techniques for mice have the potential to revolutionize the molecular genetic analysis of mouse development. Insertional mutagenesis by the introduction of exogenous DNA into the mouse germline hs permitted the molecular cloning and analysis of several novel genes important for early embryonic development. Targeted mutagenesis by homologous recombination in embryonic stem cells...

Topics

Alleles
Animals
Disease Models, Animal
Genes
Humans
Hypoxanthine Phosphoribosyltransferase
Mice
Mutagenesis, Insertional
Mutagenesis, Site-Directed

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1777476

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1777476-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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