Article
Gene disruption in mammals.
Current opinion in genetics & development - 1 Aug 1991
Rossant J
Abstract excerpt
In the past year, the first phenotypes have been reported for mutations targeted to developmentally relevant genes by homologous recombination in embryonic stem cells. The results indicate that the genetic circuitry of mammalian development is complex and will require more sophisticated analysis than simple gene disruption. Improvements in the technology of targeted mutagenesis may assist in such analysis.
Topics
- Animals
- Embryonic and Fetal Development
- Genes, Homeobox
- Genetic Vectors
- Growth Substances
- Mammals
- Morphogenesis
- Mutagenesis
- Mutagenesis, Insertional
- Phenotype
- Transcription Factors