Insertional mutagenesis in transgenic mice.

doi:10.1007/BF02336773

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Article

Insertional mutagenesis in transgenic mice.

Transgenic research - 1 Jul 1994

Rijkers T, Peetz A, Rüther U

Abstract excerpt

Increasing numbers of transgenic mouse lines have resulted in several dozens of mutants created by insertional mutagenesis. The advantages of different vector systems and the problems associated with the analysis of mutations and the cloning of the affected genes are discussed in this review.

Topics

Animals
DNA
Female
Genes, Lethal
Genetic Vectors
Humans
Male
Mice
Mice, Transgenic
Microinjections
Mutagenesis, Insertional
Mutation
Pregnancy
Retroviridae

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