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Article

Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL.

Nature medicine - 1 Sept 2007

Wagner Klaus W, Punnoose Elizabeth A, Januario Thomas, Lawrence David A, Pitti Robert M, Lancaster Kate, Lee Dori, von Goetz Melissa, Yee Sharon Fong, Totpal Klara, Huw Ling, Katta Viswanatham, Cavet Guy, Hymowitz Sarah G, Amler Lukas, Ashkenazi Avi

Abstract excerpt

Apo2L/TRAIL stimulates cancer cell death through the proapoptotic receptors DR4 and DR5, but the determinants of tumor susceptibility to this ligand are not fully defined. mRNA expression of the peptidyl O-glycosyltransferase GALNT14 correlated with Apo2L/TRAIL sensitivity in pancreatic carcinoma, non-small-cell lung carcinoma and melanoma cell lines, and up to 30% of samples from various human malignancies...

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Share to Carcinoma, Non-Small-Cell Lung
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Receptors, TNF-Related Apoptosis-Inducing Ligand

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Source

Identifiers

PMID: 17767167
DOI: 10.1038/nm1627

Genes

GALNT14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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