Article
Branched I antigen regulated cell susceptibility against natural killer cytotoxicity through its N-linked glycosylation and overall expression.
Glycobiology - 3 Jun 2021
Wu Yu-Xuan, Lu Hsu-Feng, Lin Yen-Hsi, Chuang Hui-Yu, Su Shih-Chi, Liao Yi-Jen, Twu Yuh-Ching
Abstract excerpt
Cell surface glycosylation has been known as an important modification process that can be targeted and manipulated by malignant cells to escape from host immunosurveillance. We previously showed that the blood group branched I antigen on the leukemia cell surface can regulate the cell susceptibility against natural killer (NK) cell-mediated cytotoxicity through interfering target-NK interaction. In this work, we...
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