Article
Modulation of the CD95-induced apoptosis: the role of CD95 N-glycosylation.
PloS one - 1 Jan 2011
Shatnyeva Olga M, Kubarenko Andriy V, Weber Claudia E M, Pappa Alexander, Schwartz-Albiez Reinhard, Weber Alexander N R, Krammer Peter H, Lavrik Inna N
Abstract excerpt
Protein modifications of death receptor pathways play a central role in the regulation of apoptosis. It has been demonstrated that O-glycosylation of TRAIL-receptor (R) is essential for sensitivity and resistance towards TRAIL-mediated apoptosis. In this study we ask whether and how glycosylation of CD95 (Fas/APO-1), another death receptor, influences DISC formation and procaspase-8 activation at the CD95 DISC...
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