Article
Immature truncated O-glycophenotype of cancer directly induces oncogenic features.
Proceedings of the National Academy of Sciences of the United States of America - 30 Sept 2014
Radhakrishnan Prakash, Dabelsteen Sally, Madsen Frey Brus, Francavilla Chiara, Kopp Katharina L, Steentoft Catharina, Vakhrushev Sergey Y, Olsen Jesper V, Hansen Lars, Bennett Eric P, Woetmann Anders, Yin Guangliang, Chen Longyun, Song Haiyan, Bak Mads, Hlady Ryan A, Peters Staci L, Opavsky Rene, Thode Christenze, Qvortrup Klaus, Schjoldager Katrine T-B G, Clausen Henrik, Hollingsworth Michael A, Wandall Hans H
Abstract excerpt
Aberrant expression of immature truncated O-glycans is a characteristic feature observed on virtually all epithelial cancer cells, and a very high frequency is observed in early epithelial premalignant lesions that precede the development of adenocarcinomas. Expression of the truncated O-glycan structures Tn and sialyl-Tn is strongly associated with poor prognosis and overall low survival. The genetic and...
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