Article
Receptor-selective mutants of apoptosis-inducing ligand 2/tumor necrosis factor-related apoptosis-inducing ligand reveal a greater contribution of death receptor (DR) 5 than DR4 to apoptosis signaling.
The Journal of biological chemistry - 21 Jan 2005
Kelley Robert F, Totpal Klara, Lindstrom Stephanie H, Mathieu Mary, Billeci Karen, Deforge Laura, Pai Roger, Hymowitz Sarah G, Ashkenazi Avi
Abstract excerpt
Apoptosis-inducing ligand 2 (Apo2L), also called tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), triggers programmed cell death in various types of cancer cells but not in most normal cells. Apo2L/TRAIL is a homotrimeric protein that interacts with five receptors: death receptor 4 (DR4) and DR5 mediate apoptosis activation, whereas decoy receptor 1 (DcR1), DcR2, and osteoprotegerin counteract...
Topics
- Apoptosis
- Apoptosis Regulatory Proteins
- Humans
- Jurkat Cells
- Membrane Glycoproteins
- Models, Molecular
- Mutation
- Protein Conformation
- Receptors, TNF-Related Apoptosis-Inducing Ligand
- Receptors, Tumor Necrosis Factor
- Signal Transduction