Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

O-glycans on death receptors in cells modulate their sensitivity to TRAIL-induced apoptosis through affecting on their stability and oligomerization.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Sept 2020

Jiang Yuliang, Wen Tao, Yan Rui, Kim Su-Ryun, Stowell Sean R, Wang Wenyi, Wang Yingchun, An Guangyu, Cummings Richard D, Ju Tongzhong

Abstract excerpt

The TNF-related apoptosis-inducing ligand (TRAIL) triggers apoptosis in cells by signaling through the O-glycosylated death receptors (DR4 and DR5), but the sensitivity to TRAIL-induced apoptosis of cells varies, and the attributes of this phenomenon are complex. Human carcinoma cells often express truncated O-glycans, Tn (GalNAcα1-Ser/Thr), and Sialyl-Tn (Siaα2-6GalNAcα1-Ser/Thr, STn) on their surface...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Tumor-Associated, Carbohydrate
Share to Jurkat Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Chaperones

Share to Polysaccharides

Share to Protein Multimerization

Share to Protein Stability

Share to Receptors, TNF-Related Apoptosis-Inducing Ligand

Share to TNF-Related Apoptosis-Inducing Ligand

Source

Identifiers

PMID: 32692906
DOI: 10.1096/fj.201900053RR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

O-glycans on death receptors in cells modulate their sensitivity to TRAIL-induced apoptosis through affecting on their stability and oligomerization.PMID 32692906Read ↗

Cosmc transfection decreases malignant behavior of Tn+ cells and enhances sensitivity to apoptosis when induced by Apo2L/TRAIL via alteration of O-glycan structure.Semantic proximity Read ↗

Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL.Semantic proximity Read ↗

Core Fucosylation Mediated by the FucT-8 Enzyme Affects Trail-Induced Apoptosis and Sensitivity to Chemotherapy in Human SW480 and SW620 Colorectal Cancer CellsSemantic proximity Read ↗

αNAC inhibition of the FADD-JNK axis plays anti-apoptotic role in multiple cancer cells.Semantic proximity Read ↗

Aberrant N-glycosylation in cancer: MGAT5 and β1,6-GlcNAc branched N-glycans as critical regulators of tumor development and progression.Semantic proximity Read ↗

Mucins and Truncated O-Glycans Unveil Phenotypic Discrepancies between Serous Ovarian Cancer Cell Lines and Primary Tumours.Semantic proximity Read ↗

Modulation of the CD95-induced apoptosis: the role of CD95 N-glycosylation.Semantic proximity Read ↗

Dynamic O-GlcNAcylation coordinates etoposide-triggered tumor cell pyroptosis by regulating p53 stabilitySemantic proximity Read ↗

Structure-guided engineering of the affinity and specificity of CARs against Tn-glycopeptides.Semantic proximity Read ↗

The Role of Sialyl-Tn in CancerSemantic proximity Read ↗

Receptor-selective mutants of apoptosis-inducing ligand 2/tumor necrosis factor-related apoptosis-inducing ligand reveal a greater contribution of death receptor (DR) 5 than DR4 to apoptosis signaling.Semantic proximity Read ↗

Immature truncated O-glycophenotype of cancer directly induces oncogenic features.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.