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Article

HuR Contributes to TRAIL Resistance by Restricting Death Receptor 4 Expression in Pancreatic Cancer Cells

7 Apr 2016

Abstract excerpt

UNLABELLED: Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal cancers, in part, due to resistance to both conventional and targeted therapeutics. TRAIL directly induces apoptosis through engagement of cell surface Death Receptors (DR4 and DR5), and has been explored as a molecular target for cancer treatment. Clinical trials with recombinant TRAIL and DR-targeting agents, however, have failed to...

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PMID: 27053682
DOI: 10.1158/1541-7786.mcr-15-0448

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HuR Contributes to TRAIL Resistance by Restricting Death Receptor 4 Expression in Pancreatic Cancer CellsPMID 27053682Read ↗

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Effect of Small Nucleolar RNA H/ACA Box 64 (SNORA64) on Apoptosis Regulator Genes in Pancreatic Cancer in VitroSemantic proximity Read ↗

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pADP-ribosylation regulates the cytoplasmic localization, cleavage, and pro-apoptotic function of HuR.Semantic proximity Read ↗

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