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Article

Mutational analysis of leucine 47 in human epidermal growth factor.

Journal of cellular biochemistry - 1 Jul 1991

Matsunami R K, Yette M L, Stevens A, Niyogi S K

Abstract excerpt

Seven site-specific mutants (including changes to other hydrophobic, charged, and heterocyclic amino acids) of leucine 47 of human epidermal growth factor (EGF) were generated by protein engineering and characterized for their activity in three assays: radioreceptor competition binding in membrane fractions, the stimulation of the EGF receptor's tyrosine kinase activity, and the stimulation of thymidine uptake in...

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Identifiers

PMID: 1774224
DOI: 10.1002/jcb.240460307

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutational analysis of leucine 47 in human epidermal growth factor.PMID 1774224Read ↗

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