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Article

Structure-function relationships in human epidermal growth factor studied by site-directed mutagenesis and 1H NMR.

Biochemistry - 10 Sept 1991

Hommel U, Dudgeon T J, Fallon A, Edwards R M, Campbell I D

Abstract excerpt

In order to elucidate the mechanism of interaction between human epidermal growth factor (EGF) and its receptor, selected variants of EGF, differing by single amino acid substitutions, have been made by site-directed mutagenesis. The receptor affinity of these mutants was determined by a receptor binding competition assay, and the effects of the substitution on the structure of the protein were assessed by 1H...

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Source

Identifiers

PMID: 1909576
DOI: 10.1021/bi00100a024

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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