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Article

Structure-function studies of nerve growth factor: functional importance of highly conserved amino acid residues.

The EMBO journal - 1 May 1990

Ibáñez C F, Hallböök F, Ebendal T, Persson H

Abstract excerpt

Selected amino acid residues in chicken nerve growth factor (NGF) were replaced by site-directed mutagenesis. Mutated NGF sequences were transiently expressed in COS cells and the yield of NGF protein in conditioned medium was quantified by Western blotting. Binding of each mutant to NGF receptors on PC12 cells was evaluated in a competition assay. The biological activity was determined by measuring stimulation...

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Identifiers

PMID: 2328722
DOI: 10.1002/j.1460-2075.1990.tb08265.x
PMCID: PMC551838

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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