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Article

Receptor recognition by histidine 16 of human epidermal growth factor via hydrogen-bond donor/acceptor interactions.

Journal of cellular biochemistry - 1 Jan 1999

Nandagopal K, Terzaghi-Howe M, Niyogi S K

Abstract excerpt

Human epidermal growth factor (hEGF) and human transforming growth factor alpha (hTGFalpha) are prototypical of structurally related polypeptide mitogens which interact with the epidermal growth factor receptor (EGFR). Several determinants of receptor recognition that specify function have been proposed on the basis of structural criteria. This study evaluates the role of one such candidate, H16 of hEGF, by...

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Source

Identifiers

PMID: 10025663
DOI: 10.1002/(sici)1097-4644(19990101)72:1<16::aid-jcb3>3.0.co;2-x

Genes

EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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