Article
Resistance to receptor-mediated degradation of a murine epidermal growth factor analogue (EGF-Val-47) potentiates its mitogenic activity.
Biochemistry - 27 Nov 1990
Walker F, Nice E, Fabri L, Moy F J, Liu J F, Wu R, Scheraga H A, Burgess A W
Abstract excerpt
In most cell types two classes of epidermal growth factor (EGF) receptors can be found: a major class that binds EGF with relatively low affinity and a minor class that binds with very high affinity. Structure-function studies have shown that mutations at amino acid 47 in the EGF molecule severel...
Topics
- Animals
- Biological Transport
- Epidermal Growth Factor
- ErbB Receptors
- Half-Life
- Kinetics
- Mice
- Mitogens
- Mutation
- Structure-Activity Relationship