Article
Resistance to receptor-mediated degradation of a murine epidermal growth factor analogue (EGF-Val-47) potentiates its mitogenic activity.
Biochemistry - 27 Nov 1990
Walker F, Nice E, Fabri L, Moy F J, Liu J F, Wu R, Scheraga H A, Burgess A W
Abstract excerpt
In most cell types two classes of epidermal growth factor (EGF) receptors can be found: a major class that binds EGF with relatively low affinity and a minor class that binds with very high affinity. Structure-function studies have shown that mutations at amino acid 47 in the EGF molecule severely reduce its affinity for the EGF receptor but do not cause preferential binding to one or the other subclass of...
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