Article
Low dietary riboflavin but not folate predicts increased fracture risk in postmenopausal women homozygous for the MTHFR 677 T allele.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jan 2008
Yazdanpanah Nahid, Uitterlinden André G, Zillikens M Carola, Jhamai Mila, Rivadeneira Fernando, Hofman Albert, de Jonge Robert, Lindemans Jan, Pols Huibert Ap, van Meurs Joyce B
Abstract excerpt
UNLABELLED: The MTHFR C677T polymorphism is associated with mildly elevated homocysteine levels when folate and/or riboflavin status is low. Furthermore, a mildly elevated homocysteine level is a risk factor for osteoporotic fractures. We studied whether dietary intake of riboflavin and folate modifies the effects of the MTHFR C677T variant on fracture risk in 5,035 men and women from the Rotterdam Study. We...
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