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Article

Pharmacogenomics of methadone maintenance treatment.

Pharmacogenomics - 1 May 2014

Somogyi Andrew A, Barratt Daniel T, Ali Robert L, Coller Janet K

Abstract excerpt

Methadone is the major opioid substitution therapy for opioid dependence. Dosage is highly variable and is often controlled by the patient and prescriber according to local and national policy and guidelines. Nevertheless many genetic factors have been investigated including those affecting its metabolism (CYP2B6-consistent results), efflux transport (P-gp-inconsistent results), target μ-opioid receptor (μ-opioid...

Read the complete abstract on PubMed

Topics

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Share to Dose-Response Relationship, Drug
Share to ABCB1 gene
Share to DRD2 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to OPRM1 gene

Share to Methadone

Share to Pharmacogenetics

Share to Polymorphism, Single Nucleotide

Share to Receptors, Opioid, mu

Source

Identifiers

PMID: 24956254
DOI: 10.2217/pgs.14.56

Genes

DRD2
ABCB1
ARRB2
OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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