Article
A discordance between cytochrome P450 2D6 genotype and phenotype in patients undergoing methadone maintenance treatment.
British journal of clinical pharmacology - 1 Aug 2003
Shiran M R, Chowdry J, Rostami-Hodjegan A, Ellis S W, Lennard M S, Iqbal M Z, Lagundoye O, Seivewright N, Tucker G T
Abstract excerpt
AIMS: To assess CYP2D6 activity and genotype in a group of patients undergoing methadone maintenance treatment (MMT). METHODS: Blood samples from 34 MMT patients were genotyped by a polymerase chain reaction-based method, and results were compared with CYP2D6 phenotype (n = 28), as measured by th...
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