Article
Specific polymorphic variation in the mitochondrial genome and increased in-hospital mortality after severe trauma.
Annals of surgery - 1 Sept 2007
Canter Jeffrey A, Norris Patrick R, Moore Jason H, Jenkins Judith M, Morris John A
Abstract excerpt
OBJECTIVE: To determine whether specific genetic variations in the mtDNA that impact energy production and free-radical generation are potential new risk factors for in-hospital mortality after severe trauma. SUMMARY BACKGROUND DATA: Each of the 3 mitochondrial DNA polymorphisms selected for this study (at positions 4216, 10398, 4917) alter the amino acid sequence of different key subunits of Complex I in the...
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