Association of mitochondrial allele 4216C with increased risk for complicated sepsis and death after traumatic injury.

doi:10.1097/TA.0b013e3181991ac8

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Article

Association of mitochondrial allele 4216C with increased risk for complicated sepsis and death after traumatic injury.

The Journal of trauma - 1 Mar 2009

Gomez Ruben, O'Keeffe Terence, Chang Ling-Yu, Huebinger Ryan M, Minei Joseph P, Barber Robert C

Abstract excerpt

OBJECTIVES: Numerous studies have linked impaired mitochondrial activity with increased risk for clinical complications after injury. Furthermore, a number of nonsynonymous polymorphisms have been identified within the mitochondrial genome that are believed to impair cellular respiration. These DNA variants include a nonsynonymous polymorphism (T4216C) in the NADH dehydrogenase 1 gene (ND1), which encodes a key...

Topics

Adult
Age Factors
Aged
Alleles
Cohort Studies
Erythrocyte Transfusion
Female
Genetic Carrier Screening
Genotype
Humans
Injury Severity Score
Male
Middle Aged
Multiple Organ Failure

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multivariate Analysis

NADH Dehydrogenase

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Source

Open in PubMed

Identifiers

PMID: 19276764
DOI: 10.1097/TA.0b013e3181991ac8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.