Article
Genetic variation in complement component 2 of the classical complement pathway is associated with increased mortality and infection: a study of 627 patients with trauma.
The Journal of trauma - 1 May 2009
Morris John A, Francois Cedric, Olson Paul K, Cotton Bryan A, Summar Marshall, Jenkins Judith M, Norris Patrick R, Moore Jason H, Williams Anna E, McNew Brent S, Canter Jeffrey A
Abstract excerpt
BACKGROUND: Trauma is a disease of inflammation. Complement Component 2 (C2) is a protease involved in activation of complement through the classical pathway and has been implicated in a variety of chronic inflammatory diseases. We hypothesized that genetic variation in C2 (E318D) identifies a high-risk subgroup of patients with trauma reflecting increased mortality and infection (ventilator-associated pneumonia...
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