Article
Mitochondrial DNA and traumatic brain injury.
Annals of neurology - 1 Feb 2014
Bulstrode Harry, Nicoll James A R, Hudson Gavin, Chinnery Patrick F, Di Pietro Valentina, Belli Antonio
Abstract excerpt
OBJECTIVE: Traumatic brain injury (TBI) is a multifactorial pathology with great interindividual variability in response to injury and outcome. Mitochondria contain their own DNA (mtDNA) with genomic variants that have different physiological and pathological characteristics, including susceptibility to neurodegeneration. Given the central role of mitochondria in the pathophysiology of neurological injury, we...
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