Article
An insight into the role of phosphotransacetylase (pta) and the acetate/acetyl-CoA node in Escherichia coli.
Microbial cell factories - 24 Oct 2009
Castaño-Cerezo Sara, Pastor José M, Renilla Sergio, Bernal Vicente, Iborra José L, Cánovas Manuel
Abstract excerpt
BACKGROUND: Acetate metabolism in Escherichia coli plays an important role in the control of the central metabolism and in bioprocess performance. The main problems related to the use of E. coli as cellular factory are i) the deficient utilization of carbon source due to the excretion of acetate during aerobic growth, ii) the inhibition of cellular growth and protein production by acetate and iii) the need for...
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