Coordinated activation of PTA-ACS and TCA cycles strongly reduces overflow metabolism of acetate in Escherichia coli.

doi:10.1007/s00253-014-5613-y

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Article

Coordinated activation of PTA-ACS and TCA cycles strongly reduces overflow metabolism of acetate in Escherichia coli.

Applied microbiology and biotechnology - 1 Jun 2014

Peebo Karl, Valgepea Kaspar, Nahku Ranno, Riis Gethe, Oun Mikk, Adamberg Kaarel, Vilu Raivo

Abstract excerpt

Elimination of acetate overflow in aerobic cultivation of Escherichia coli would improve many bioprocesses as acetate accumulation in the growth environment leads to numerous negative effects, e.g. loss of carbon, inhibition of growth, target product synthesis, etc. Despite many years of studies, the mechanism and regulation of acetate overflow are still not completely understood. Therefore, we studied the growth...

Topics

Acetates
Aerobiosis
Escherichia coli K12
Gene Expression Regulation, Bacterial
Glucose
Metabolic Flux Analysis
Metabolic Networks and Pathways
Metabolome
Metabolomics
Mutation
Proteome
Proteomics

Source

Open in PubMed

Identifiers

PMID: 24633370
DOI: 10.1007/s00253-014-5613-y

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