Article
Thermodynamically reengineering the listerial invasion complex InlA/E-cadherin.
Proceedings of the National Academy of Sciences of the United States of America - 28 Aug 2007
Wollert Thomas, Heinz Dirk W, Schubert Wolf-Dieter
Abstract excerpt
Biological processes essentially all depend on the specific recognition between macromolecules and their interaction partners. Although many such interactions have been characterized both structurally and biophysically, the thermodynamic effects of small atomic changes remain poorly understood. Based on the crystal structure of the bacterial invasion protein internalin (InlA) of Listeria monocytogenes in complex...
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