Article
The modular architecture of protein-protein binding interfaces.
Proceedings of the National Academy of Sciences of the United States of America - 4 Jan 2005
Reichmann D, Rahat O, Albeck S, Meged R, Dym O, Schreiber G
Abstract excerpt
Protein-protein interactions are essential for life. Yet, our understanding of the general principles governing binding is not complete. In the present study, we show that the interface between proteins is built in a modular fashion; each module is comprised of a number of closely interacting residues, with few interactions between the modules. The boundaries between modules are defined by clustering the contact...
Topics
- Bacterial Proteins
- Binding Sites
- Models, Molecular
- Mutation
- Protein Binding
- Protein Structure, Tertiary
- Proteins
- Thermodynamics
- beta-Lactamases